Mechanisms of DNA damage by chromium(V) carcinogens
نویسندگان
چکیده
منابع مشابه
Mechanisms of DNA damage by chromium(V) carcinogens.
Reactions of bis(2-ethyl-2-hydroxy-butanato)oxochromate(V) with pUC19 DNA, single-stranded calf thymus DNA (ss-ctDNA), a synthetic oligonucleotide, 5'-GATCTATGGACTTACTTCAAGGCCGGGTAATGCTA-3' (35mer), deoxyguanosine and guanine were carried out in Bis-Tris buffer at pH 7.0. The plasmid DNA was only nicked, whereas the single-stranded DNA suffered extensive damage due to oxidation of the ribose mo...
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leagues of the Institute of Toxicology in Karlsruhe have published data on a gene expression based predictive test system for chemical carcinogens (Fischer et al., 2015). The authors used bronchial epithelial cell lines and analyzed the expression of 95 genes by a high-throughput RT-qPCR system. The analyzed genes cover the biological motifs DNA damage response, genomic stability , cell cycle c...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1998
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/26.7.1588